MONDAY, 14 June(Sessions start at 8:00 AM Pacific Standard Time each day) |
8:00 Larry Sherman and Paul Bollyky
Welcome to the meeting
8:05 Tony Day – ISHAS President
Opening of the Conference
Introduction to the Rooster Prize
8:10 Carol de la Motte
Tribute to Vince Hascall
8:20 Vince Hascall
Rooster Prize Talk
8:50 Q&A
8:55 Tony Day
Presentation of Rooster Prize
9:00 Break
9:15 Ralf Richter
Introduction to the Keynote Presentation
9:20 Gijsje Koenderink
Keynote talk
BIOPHYSICS OF HYALURONAN ACROSS SCALES
10:05 Q&A
10:10 Break
10:40 Session I – HA Metabolism and Synthesis
Chair and Moderator: Soma Meran
Invited Speaker: Alberto Passi
THE HARD WORK OF CONTROLLING HYALURONAN SYNTHESIS
11:00 Q&A
11:05 Mariángeles Díaz
4-METHYLUMBELLIFERONE INDUCES ANTI-TUMOR EFFECTS INDEPENDENTLY OF ITS ROLE AS A HYALURONAN SYNTHESIS INHIBITOR ON HUMAN ACUTE MYELOID LEUKEMIA CELLS
11:15 Q&A
11:20 Fumitoshi Irie
TMEM2 BINDS INTEGRINS AND REGULATES TUMOR CELL ADHESION AND MIGRATION VIA DEGRADATION OF HYALURONAN AT FOCAL ADHESION SITES
11:30 Q&A
11:35 Brenna Zimmer
UGDH IS A NOVEL SENSORY NODE IN PROSTATE ANDROGEN RESPONSE
11:45 Q&A
11:50 Break
12:00 Session II – HA in Signaling and Cell Biology
Chair and Moderator: Eva Turley
Invited Speaker: Raphaël Rodriguez
CD44 MEDIATES METAL UPTAKE AND REGULATES CANCER PROGRESSION
12:20 Q&A
12:25 Michele Pritchard
HYALURONAN SYNTHESIS INHIBITION NORMALIZES ETHANOL-ENHANCED HEPATIC STELLATE CELL ACTIVATION
12:35 Q&A
12:40 Alec Peters
CELL MIGRATION INDUCING AND HYALURONAN BINDING PROTEIN (CEMIP) IS DYSREGULATED IN DEMYELINATING DISEASE AND REGULATES OLIGODENDROCYTE PROGENITOR CELL DIFFERENTIATION
12:50 Q&A
12:55 Rashmin C. Savani
RHAMM AND HYALURONAN ARE CRITICAL TO THE TOLL-LIKE RECEPTOR 7- AND SARS- CoV-2-MEDIATED CYTOKINE STORM AND INFLAMMATION
1:05 Q&A
1:10 Break
1:25 Poster Q&A Concurrent Sessions 1 and 2
Poster Session 1: HA SYNTHESIS AND METABOLISM
Chair and Moderator: Stavros Garantziotis
1:25 Anja Schmaus - HIGHLY SULFATED HYALURONIC ACID POTENTLY INHIBITS CEMIP HYALURONIDASE ACTIVITY, AND REGULATES THE HA METABOLISM, PROLIFERATION AND DIFFERENTIATION OF FIBROBLASTS
1:30 Aimin Wang - NEW PERSPECTIVES: THE ROLES OF HEXOSAMINE BIOSYNTHETIC PATHWAY IN DIABETIC COMPLICATIONS AND THERAPIES
1:35 Rebekka Schneckmann - ENDOTHELIAL HYALURONAN SYNTHASE 3 AUGMENTS POST-ISCHEMIC ARTERIOGENESIS THROUGH CD44/ENOS SIGNALING
1:40 Irina Grigorieva - THE ROLE OF THE HYALURONAN SYNTHASE 2-ANTISENSE (HAS2-AS1) LNC-RNA IN REGULATION OF HA-MEDIATED FIBROTIC CELLULAR RESPONSES
1:45 Irina Grigorieva - ISCHAEMIC PRE-CONDITIONING (IPC) DRIVES EXPANSION OF A PROTECTIVE HAS1 POSITIVE CELL POPULATION IN THE RENAL STROMA, TUBULES AND VASCULATURE
1:50 Tom Wippold - COMPLETE DEPLETION OF HYALURONAN SYNTHASE ACTIVITY IN MURINE SKIN LEADS TO DELAYED WOUND HEALING
1:55 Sarah Buckby - HYALURONIDASE-2 AS A REGULATOR OF DNA
2:00 Jennifer McCracken - RECAPITULATING POST-MENOPAUSAL VAGINAL ENVIRONMENT IN A MURINE MODEL AFTER BILATERAL OOPHERECTOMY
2:05 Ina Sevic - HYALURONAN METABOLISM IS ASSOCIATED WITH DNA REPAIR GENES IN BREAST AND COLORECTAL CANCER
2:10 Laia Saltor Núñe - DERIVATIZATION OF HYALURONAN FOR MUCIN-LIKE STRUCTURES IN GLYCOCALYX MODELS
2:15 Bernard van den Berg - HYPER GLYCOLYSIS REDUCES ENDOTHELIAL HYALURONAN SYNTHESIS IN TUMOR VESSELS
2:20 Wendena S. Parkes - HYALURONAN AND COLLAGEN ARE PROMINENT EXTRACELLULAR MATRIX COMPONENTS IN BOVINE AND PORCINE OVARIES
2:25 Hitoshi Kurihara - METABOLISM AND SKIN IMPROVING EFFECTS OF ORALLY INGESTED HYALURONAN
2:30 Daiana Vitale - COMBINATION OF TREATMENT WITH HYALURONAN PLUS DOXORUBICIN ON HEMATOPOIETIC AND SOLID TUMOR CELLS AFFECTS ENDOTHELIAL CELL BEHAVIOR INDEPENDENTLY OF VEGF EXPRESSION
2:35 Elnur Babayev - CUMULUS CELL EXPANSION AND THE HYALURONIC ACID MATRIX DO NOT CHANGE WITH ADVANCED REPRODUCTIVE AGE
2:40 Molly I Abraham - GENETIC KNOCKDOWN OF HYALURONAN SYNTHASE ENZYMES ALTERS PROCESS OUTGOWTH OF DEVELOPING HIPPOCAMPAL NEURONS IN VITRO
Poster Session 2: HA IN SIGNALING AND CELL BIOLOGY
Chair and Moderator: Nadine Nagy
1:25 Michael P. Lockhart-Cairns - TOWARDS A STRUCTURE OF PTX-3: INSIGHTS INTO ITS INTERACTIONS WITH IαI HEAVY CHAINS THAT MEDIATE HA CROSSLINKING
1:30 Dorothea Erxleben - SELECTIVE ISOLATION OF HEAVY CHAIN-MODIFIED HYALURONAN FOR MOLECULAR ANALYSIS
1:35 Yan Wang - INCREASED MYOFIBROBLAST DIFFERENTIATION IN HYALURONAN SYNTHASE-1/3 NULL MICE IS MEDIATED BY ENHANCED SRF/MRTF FUNCTION DRIVEN BY AN MMP/TGFβR/P38MAPK SIGNALING PATHWAY
1:40 Yu Jing - DIRECT EVIDENCE OF HYALURONAN EXPRESSED AT THE CELL-SUBSTRATUM EXERTS FORCES THAT MODIFY CELL ADHESION
1:45 Richard Scharff - METAL ION DEPENDENT SELF-ASSOCIATION OF PRE-ALPHA-INHIBITOR HEAVY CHAIN 3 (ITIH3)
1:50 Britney Messam - THE RECEPTOR FOR HYALURONAN-MEDIATED MOTILITY AS A REGULATOR OF DRUG SENSITIVITY IN TRIPLE-NEGATIVE BREAST CANCER
1:55 Suniti Misra - A POSITIVE FEEDBACK LOOP BETWEEN β-CATENIN/MDR1 SIGNALING AND CD44V6 SPLICING SUSTAINS CHEMORESISTANCE OF CANCER INITIATING CELLS IN COLORECTAL CANCER
2:00 Yu-Hsuan Huang - CHONDROITIN SULFATE NEGATIVELY REGULATES HYALURONAN BINDING AND MELANOMA METASTASIS TO THE LUNG
2:05 Daniela Poodts - CD44 AND RHAMM AS KEY PLAYERS IN HA-MEDIATED GLIOBLASTOMA MIGRATION
2:10 Constantinos Kolliopoulos - TRAF4/6 IS NEEDED FOR CD44 CLEAVAGE AND MIGRATION VIA RAC1 ACTIVATION
2:15 Lydia-Nefeli Thrapsanioti - LOW MOLECULAR WEIGHT HYALURONAN STIMULATES RHAMM/β-CATENIN COMPLEX FORMATION, β-CATENIN NUCLEAR TRANSLOCATION AND DOWNSTREAM SIGNALING IN HT1080 CELLS
2:20 Martin Šindelář - BIOINFORMATIC ANALYSIS OF TALAROMYCES HYALURONIDASES WITHIN GLYCOSIDE HYDROLASE SUBFAMILY GH16
2:25 Katerina Dostalova - THE EFFECT OF EXOGENOUS HYALURONAN ON MYOFIBROBLAST DIFFERENTIATION IN THE IN VITRO MODEL OF PERITONEAL MEMBRANE
2:30 Irina Grigorieva - THE TRANSCRIPTION FACTOR GATA3 IS AN IMPORTANT REGULATOR OF HA-MEDIATED RESPONSES IN KIDNEY FIBROSIS PROGRESSION VERSUS FIBROSIS RESOLUTION
End of Day 1
Tuesday, 15 June(Sessions start at 8:00 AM Pacific Standard Time each day) |
8:00 Panel Discussion for Trainees
Moderator: Larry Sherman
Panelists: Glenn Prestwich, Soma Meran, Melanie Simpson
8:30 Session III – HA in Stem Cells, Development, and Aging
Chair and Moderator: Barbara Triggs-Raine
Invited Speaker: Andrew Dillin
THE UNEXPECTED ROLE OF TMEM2 AND HYALURONAN IN ER STRESS AND AGING
8:50 Q&A
8:55 Taasin Srivastava
HYALURONAN MATRIX REMODELING DURING BRAIN DEVELOPMENT
9:05 Q&A
9:10 Robert B. Vernon
AUTOCRINE HYALURONAN INFLUENCES SPROUTING AND LUMEN FORMATION DURING HUVEC TUBULOGENESIS IN VITRO
9:20 Q&A
9:25 Break
9:45 Session IV – HA in Disease
Moderator: Melanie Simpson
Invited Speaker: David Lyden
TUMOR-DERIVED CEMIP PROMOTES BRAIN METASTASIS
10:05 Q&A
10:10 Invited Speakers: Alexandra Donlan and Tara Sutherland
IL-13 IS THE DRIVER OF HA BIOSYNTHESIS UNDERPINNING SEVERITY OF COVID-19
10:30 Q&A
10:35 Nadine Nagy
HYALURONAN PROMOTES DISEASE PROGRESSION IN PRIMARY SCLEROSING CHOLANGITIS
10:45 Q&A
10:50 Aaron C. Petrey
GLYCOCALYX DEGRADATION IN COVID-19 RELEASES HYALURONAN FRAGMENTS WHICH CAN DIRECTLY INDUCE ENDOTHELIAL BARRIER DYSFUNCTION
11:00 Q&A
11:05 Michael J. Kratochvil
HYALURONAN CONTRIBUTES TO THE BIOCHEMICAL AND BIOPHYSICAL PROPERTIES OF RESPIRATORY SECRETIONS IN SEVERE SARS-COV-2 (COVID-19) INFECTIONS
11:15 Q&A
11:20 Break
11:50 Session V – Advances in HA Biotechnology
Chair and Moderator: Anna Plaas
Invited Speaker: Jennifer Curtis
HYALURONAN FORCES IN CELL ADHESION PROBED WITH TUNABLE GLYCOCALYX
12:10 Q&A
12:15 Theodoros Karalis
A NOVEL SMALL MOLECULE INHIBITOR OF HYALURONAN SYNTHESIS
12:25 Q&A
12:30 Stavros Garantziotis
HIGH MOLECULAR WEIGHT HYALURONAN AMELIORATES INFECTION WITH SARS-COV2
12:40 Q&A
12:45 Diana Egorova
A RAPID AND HIGH-THROUGHPUT METHOD FOR ANALYZING MOLECULAR WEIGHT OF HYALURONAN IN ANIMAL TISSUE SAMPLES
12:55 Q&A
1:00 Break
1:15 Poster Q&A Concurrent Sessions 3 and 4
Poster Session 3: HA in Stem Cells, Development, Aging, and Disease
Chair and Moderator: Stavros Garantziotis
1:15 Corinne Demler - DIFFERENTIAL HYALURONAN REGULATION IS CRITICAL FOR LEFT/RIGHT ASYMMETRY IN INTESTINAL DEVELOPMENT
1:20 Shlomi Cohen - HYALRONAN REGULATES NEURAL CREST MIGRATION
1:25 Rashi Karunasinghe - THE HYALURONAN CORNERSTONE: AN EXTRACELLULAR MATRIX MOLECULE THAT REGULATES EARLY NEURITE OUTGROWTH IN HIPPOCAMPAL NEURONS
1:30 Giulia Giubertoni – INTERACTIONS BETWEEN CATIONS AND HYALURONAN: A QUESTION OF SIZE OR CHARGE?
1:35 Hector Martinez-Seara -N-GLYCOSYLATION BLOCKS AND SIMULTANEOUSLY FOSTERS DIFFERENT RECEPTOR-LIGAND BINDING SITES: THE CHAMELEONIC CD44-HYALURONAN INTERACTION
1:40 Farners Amargant – HYALURONAN SYNTHESIS IS REQUIRED FOR PREANTRAL FOLLICLE GROWTH IN THE MOUSE
1:45 Pierre Weiss - A SILATED HYALURONIC ACID HYDROGEL PLATFORM WITH BIOINSPIRED PROPERTIES FOR TISSUE ENGINEERING
1:50 Megan Hamilton - A CELL DELIVERY SYSTEM BASED ON DEGRADABLE HYALURONIC ACID MICROBEADS
1:55 Urban Hellman - SARS-CoV-2-INDUCED REGULATION OF HYALURONAN METABOLISM IN AN AIR-LIQUID INTERFACE CELL CULTURE
2:00 Stavros Garantziotis - TRANSLATIONAL APPLICATION OF HIGH MOLECULAR WEIGHT HYALURONAN IN AIRWAY DISEASE
2:05 Stephen R. Reeves - AIRWAY EPITHELIAL CELLS DISPLAY INCREASED ACCUMULATION OF HYALURONAN IN THE EXTRACELLULAR MATRIX AND ENHANCED NEUTROPHIL RETENTION FOLLOWING RESPIRATORY SYNCYTIAL VIRUS INFECTION
2:10 Marco Piroth - HYALURONAN SYNTHASE 3 DEFICIENCY RESULTS IN ADVERSE REMODELING AND DECREASED CARDIAC CD4-T-CELL ABUNDANCE AFTER ACUTE ISCHEMIA
2:15 Meghana Pendyala - HYALURONAN TURNOVER IN SYNOVIOCYTES IS SENSITIVE TO CYCLIC STRAIN MAGNITUDE
2:20 Hunter Martinez – CD44V6 PROMOTES FOXP3 TREG HOMEOSTASIS BUT ITS EXPRESSION IS REDUCED IN T1D
2:25 Shrea Roy - HYALURONAN (HA) DEPENDENT REGULATION OF VASCULAR SMOOTH MUSCLE CELL PHENOTYPE AND VASCULAR CALCIFICATION. (VC) IN CARDIORENAL DISEASE
2:30 May J Reed - VIABLE BRAIN MICROVESSELS FOR THE STUDY OF EXTRACELLULAR MATRIX IN ALZHEIMER’S DISEASE
2:35 Anna Kocurkova - ENDOGENOUS HYALURONAN IS PARTICIPATING IN DEVELOPMENT OF PERITONEAL ADHESIONS
2:40 Sofia Spataro - IDENTIFICATION OF AMINO ACIDS ESSENTIAL FOR CEMIP ACTIVITY TOWARDS EXPLORING ITS ROLE IN ALPORT SYNDROME
Poster Session 4: HA in Disease and Advances in HA Biotechnology
Chair and Moderator: Nadine Nagy
1:15 Vojtěch Pavlík - SKIN CELLS ENHANCE CHOLESTEROL METABOLISM WHEN TREATED WITH RETINOIC OR OLEIC ACID GRAFTED TO HYALURONAN
1:20 Chunyue Wang - HYALURONAN, A SCAFFOLD FOR SUPERSELECTIVE TARGETING OF TUMOUR CELLS
1:25 Mary K. Cowman - HA NETWORKING IN SOLUTION MEDIATED BY TSG-6 CAN BE DISRUPTED BY COMPETITIVE BINDING OF HEPARAN SULFATE
1:30 Arianna Parnigoni - HAS2-AS1 OVEREXPRESSION MEDIATES APOPTOSIS INDUCTION IN MDA-MB-231 TRIPLE NEGATIVE BREAST CANCER CELLS INDEPENDENTLY FROM HYALURONAN METABOLISM
1:35 - Zoe Price - THE ROLE OF MOLECULAR WEIGHT OF HYALURONAN IN OVARIAN CANCER STEM CELL SIGNALLING PATHWAYS AND CHEMORESISTANCE
1:40 Rebecca J Dodd - CHEMICAL MODIFICATION OF HYALURONAN OLIGOSACCHARIDES TO MODULATE INTERACTIONS WITH HYALURONAN-BINDING PROTEINS
1:45 Sumitra Srimasorn - SIZING HA AND OTHER GLYCOSAMINOGLYCANS ON SURFACES
1:50 Miroslava Rysová - PERFORMANCE OF HYALURONAN-NANOFIBRES CONJUGATES IN CATIONIC DRUGS DELIVERY
1:55 Celeste Di Meo - HYALURONAN SIZE AFFECTS BIOPHYSICAL AND BIOCHEMICAL FEATURES AND STABILITY PROPERTIES: CHARACTERIZATION OF A WIDE RANGE OF INCREASING MOLECULAR WEIGHT FAMILIES
2:00 Vassallo Valentina – BIOFERMENTATIVE GLYCOSAMINOGLYCANS BASED GELS MODULATE INFLAMMATION MARKERS IN OSTEOARTHRITIS IN VITRO MODEL BASED ON HUMAN PRIMARY CELLS
2:05 Antonietta Stellavato – DIFFERENT MOLECULAR WEIGHT HYALURONAN BASED GELS MAY AFFECT BONE REGENERATION THROUGH DIFFERENTIATION OF DENTAL PULP STEM CELLS
2:10 Cornelia Zapp - NATURAL PRESENTATION OF GLYCOSAMINOGLYCANS IN TUNABLE CELL-INSTRUCTIVE MICROENVIRONMENTS
2:15 Romana Šínová - USE OF UNLABELED AND LABELED HA IN STUDY OF HA EPIDERMAL PENETRATION
2:20 Chiara Schiraldi - ARE HYALURONIC ACID AND CHONDROITIN BASED GELS PLAYING A ROLE IN COMMITMENT OF MESENCHYMAL STEM CELLS TO CHONDROCYTE PROGENITORS AND IN THE DIFFERENTIATION OF PROGENITORS TO MATURE CHONDROCYTES?
2:25 Denys Biriukov - WHAT IS TRUTH AND NOT IN MOLECULAR DYNAMICS SIMULATIONS OF HYALURONAN–PEPTIDE INTERACTIONS?
2:30 Noriyuki Yuasa - BINDING PROPERTIES AND PROTECTIVE EFFECTS OF SULFATED HYALURONIC ACID ON GROWTH FACTORS
2:35 Sergey Uspenskii – MECHANISM OF THE EFFECT OF BORAX ON THE RHEOLOGICAL PROPERTIES OF SODIUM HYALURONATE SOLUTIONS
2:40 Felipe Rivas - OPTIMIZING THE QUANTITATIVE ANALYSIS OF HYALURONIC ACID WITH A SOLID-STATE NANOPORE PLATFORM
2:50 Tony Day
Presentation of Awards
2:55 Larry Sherman and Paul Bollyky
End of Meeting
